Detalhe da pesquisa
1.
Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder.
Cell
; 167(6): 1481-1494.e18, 2016 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27912058
2.
Targeting SLC transporters: small molecules as modulators and therapeutic opportunities.
Trends Biochem Sci
; 48(9): 801-814, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37355450
3.
SLC16 Family: From Atomic Structure to Human Disease.
Trends Biochem Sci
; 46(1): 28-40, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32828650
4.
Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency.
Proc Natl Acad Sci U S A
; 119(46): e2210247119, 2022 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36343260
5.
Identification of discriminative gene-level and protein-level features associated with pathogenic gain-of-function and loss-of-function variants.
Am J Hum Genet
; 108(12): 2301-2318, 2021 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34762822
6.
Protein structure-based gene expression signatures.
Proc Natl Acad Sci U S A
; 118(19)2021 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33941686
7.
Rational design of ASCT2 inhibitors using an integrated experimental-computational approach.
Proc Natl Acad Sci U S A
; 118(37)2021 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34507995
8.
PredictProtein - Predicting Protein Structure and Function for 29 Years.
Nucleic Acids Res
; 49(W1): W535-W540, 2021 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33999203
9.
Describing inhibitor specificity for the amino acid transporter LAT1 from metainference simulations.
Biophys J
; 121(23): 4476-4491, 2022 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36369754
10.
Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge.
PLoS Comput Biol
; 17(9): e1009302, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34520464
11.
Structures of ligand-occupied ß-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
Proc Natl Acad Sci U S A
; 116(16): 7819-7824, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30944224
12.
Artificial intelligence and machine learning-aided drug discovery in central nervous system diseases: State-of-the-arts and future directions.
Med Res Rev
; 41(3): 1427-1473, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33295676
13.
Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα.
Biochemistry
; 60(4): 289-302, 2021 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33440120
14.
Maternal health around pregnancy and autism risk: a diagnosis-wide, population-based study.
Psychol Med
; : 1-9, 2021 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33766168
15.
Interaction of the neutral amino acid transporter ASCT2 with basic amino acids.
Biochem J
; 477(8): 1443-1457, 2020 04 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32242892
16.
KinaMetrix: a web resource to investigate kinase conformations and inhibitor space.
Nucleic Acids Res
; 47(D1): D361-D366, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30321373
17.
High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4.
J Am Chem Soc
; 142(1): 33-37, 2020 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31841327
18.
SLC13A3 variants cause acute reversible leukoencephalopathy and α-ketoglutarate accumulation.
Ann Neurol
; 85(3): 385-395, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30635937
19.
A whole-animal platform to advance a clinical kinase inhibitor into new disease space.
Nat Chem Biol
; 14(3): 291-298, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29355849
20.
Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network.
PLoS Comput Biol
; 15(4): e1006878, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31026276